论文 (Publications) (#通讯作者, *equal contribution)
代表性论文 (Representative publications)
1)Wu Z*, Xu H*, Wang P*, Liu L*, Cai J*, Chen Y*, Zhao X, You X, Liu J, Guo X, Xie T, Feng J, Zhou F, Li R, Xie Z, Xue Y#, Fu C# and Liang Y#. 2022. The entry of unclosed autophagosomes into vacuoles and its physiological relevance. PLoS Genetics [In press]
2)Wu Z*, Xu H*, Liu J*, Zhou F and Liang Y#. 2021. The ESCRT-III complex contributes to macromitophagy in yeast. Traffic 22(8), 258-273. [PDF]
3)Zhang A*, Meng Y*, Li Q* and Liang Y#. 2020. The endosomal sorting complex required for transport complex negatively regulates Erg6 degradation under specific glucose restriction conditions. Traffic 21(7), 488-502. [PDF]
4)Zhou F, Wu Z, Zhao M, Segev N# and Liang Y#. 2019. Autophagosome closure by ESCRT: Vps21/RAB5-regulated ESCRT Recruitment via an Atg17-Snf7 Interaction. Autophagy 15(9):1653-1654. [PDF]
5)Zhou F*, Wu Z*, Zhao M, Murtazina R, Cai J, Zhang A, Li R, Sun D, Li W, Zhao L, Li Q, Zhu J, Cong X, Zhou Y, Xie Z, Gyurkovska V, Li L, Huang X, Xue Y, Chen L, Xu H, Xu H, Liang Y# and Segev N#. 2019. Rab5-dependent autophagosome closure by ESCRT. Journal of Cell Biology 218(6):1908-1927. [PDF]
6)Zhu X*, Cai J*, Zhou F, Wu Z, Li D, Li Y, Xie Z, Zhou Y and Liang Y #. 2018. Genome-wide screening of budding yeast with honokiol to associate mitochondrial function with lipid metabolism. Traffic 19(11), 867-878. [PDF]
7)Zhou F*, Zou S*, Chen Y*, Lipatova Z, Sun D, Zhu X, Li R, Wu Z, You W, Cong X, Zhou Y, Xie Z, Gyurkovska V, Liu Y, Li Q, Li W, Cheng J, Liang Y# and Segev N#. 2017. A Rab5 GTPase module is important for autophagosome closure. PLoS Genetics 13(9):e1007020. [PDF]
8)Chen Y, Zhou F, Zou S, Yu S, Li S, Li D, Song J, Li H, He Z, Hu B, Björn L, Lipatova Z, Liang Y#, Xie Z# and Segev N#. 2014. A Vps21 endocytic module regulates autophagy. Molecular Biology of the Cell 25, 3166-3177. [PDF]
9)Zou S, Chen Y, Liu Y, Segev N, Yu S, Liu Y, Min G, Ye M, Zeng Y, Zhu X, Hong B, Björn L, Liang Y#, Li S# and Xie Z#. 2013. Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae. Traffic 14, 233-246. [PDF]
10)Zou S*, Liu Y*, Zhang XQ*, Chen Y, Ye M, Zhu X, Yang S, Lipatova Z, Liang Y# and Segev N#. 2012. Modular TRAPP complexes regulate intracellular protein trafficking through multiple Ypt/Rab GTPases in Saccharomyces cerevisiae. Genetics 191, 451-460. [PDF]
11)Liang Y, Morozova N, Tokarev AA, Mulholland JW and Segev N. 2007. The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPPII complex. Molecular Biology of the Cell 18, 2533-2541. [PDF]
12)Morozova N*, Liang Y*, Tokarev AA, Chen S, Cox R, Andrejic J, Lipatova Z, Sciorra V, Emr S and Segev N. 2006. TRAPPII subunits are required for the specificity switch of a Ypt/Rab GEF. Nature Cell Biology 8, 1263-1269. [PDF]
(Research Highlight in Nature Reviews Molecular Cell Biology (2006) 7, 881; and recommended by "Faculty of 1000 Biology")
13)Liang Y and Sun W. 2002. Rate of dehydration and cumulative desiccation stress interacted to modulate desiccation tolerance of recalcitrant Theobroma cacao and Ginkgo biloba embryonic tissues. Plant Physiology 128, 1323-1331. [PDF]
14)Liang Y and Sun W. 2000. Desiccation tolerance of recalcitrant Theobroma cacao embryonic axes: the optimal drying rate and its physiological basis. Journal of Experimental Botany 51, 1911-1919. [PDF]
其它论文 (Other publications)
1)Zhao L*, You W*, Sun D, Xu H, You X, Xu H, Wu Z, Xie Z and Liang Y #. 2022. Vps21 Directs the PI3K-PI(3)P-Atg21-Atg16 Module to Phagophores via Vps8 for Autophagy. International Journal of Molecular Sciences 23, 9550. [PDF]
2)Chen Y*, Wu Z*, Dong L*, You X, Ji Y and Liang Y #. 2022. Yeast phospholipase D, Spo14, is not required for macroautophagy. Yeast 39, 401-411. [PDF]
3)Zhao M and Liang Y #. 2021. Using GBP Nanotrap to Restore Autophagy in the Rab5/Vps21 Mutant by Forcing Snf7 and Atg17 Interaction. Methods in Molecular Biology 2293, 181-188. [PDF]
4)Liang Y #. 2021. Phagophore Closure. Advances in Experimental Medicine and Biology 1208, 43-53. [PDF]
5)Li W, Wu Z and Liang Y #. 2019. Vrl1 relies on its VPS9-domian to play a role in autophagy in Saccharomyces cerevisiae. Cell Biology International 43(8), 875-889. [PDF]
6)Cheng J, Yin Z, Zhang Z and Liang Y #. 2018. Functional analysis of MoSnf7 in Magnaporthe oryzae. Fungal Genetics Biology 121, 29-45. [PDF]
7)Zhu X, Zou S, Li Y and Liang Y #. 2017. Transcriptomic analysis of Saccharomyces cerevisiae upon honokiol treatment. Research in Microbiology 168, 626-635. [PDF]
8)Yang J, Yang Z, Yin Y, Rao M, Liang Y# and Ge M#. 2016. Three novel polyene macrolides isolated from cultures of Streptomyces lavenduligriseus. Journal of Antibiotics 69, 62-65 [PDF]
9)Zou S*, Liu Y*, Zhang C, Yu S and Liang Y#. 2015. Bet3 participates in autophagy through GTPase Ypt1 in Saccharomyces cerevisiae. Cell Biology International 39, 466-474. [PDF]
10)Ye M, Chen Y, Zou S, Yu S and Liang Y#. 2014. Ypt1 suppresses defects of vesicle trafficking and autophagy in Ypt6 related mutants. Cell Biology International 38, 663-674. [PDF]
11)Jin X, Rao M, Wei W, Ge M, Liu J, Chen D and Liang Y#. 2012. Biosynthesis of new lipopentapeptides by an engineered strain of Streptomyces sp. HCCB10043. Biotechnology Letters 34, 2283-2289. [PDF]
综述 (Review)
Yu S and Liang Y. 2012. A Trapper Keeper for TRAPP, its structures and functions. Cellular and Molecular Life Sciences 69, 3933-3944. [PDF]
著作章节 (Book chapter)
梁永恒. 2021. 自噬前体的闭合. 自噬生物学与疾病(方法卷) 第3版 秦正红、乐卫东、谢志平 总主编,谢志平 主编, 科学出版社,31-38.
主要科研项目 (Fundings)
国家自然科学基金重大研究计划培育项目,未闭合自噬体与溶酶体融合的鉴定及意义(编号91954125),2020.1-2022.12,主持人。
国家自然科学基金面上项目,酿酒酵母中ESCRT复合体在自噬前体闭合中的作用及机制研究(编号31871428),2019.1-2020.12,主持人。
国家自然科学基金面上项目,酵母Vps21模块蛋白通过Vps34和PI3P调控自噬前体闭合的机制研究(编号31671479),2017.1-2020.12,主持人。
国家自然科学基金面上项目,酵母中的Ypt51与CORVET复合体互作对细胞自噬的影响(编号31271520),2013.1-2016.12,主持人。
荣誉 (Honor)
2019年度公司“钟山学术骨干B岗”;2019年江苏省优秀博士学位论文指导教师(博士生 周帆);2019年公司优秀博士学位论文指导教师(博士生 周帆);2020年公司优秀学术型硕士学位论文指导教师(硕士生 张奥);2016年、2017年、2020年、2021年、2022年公司优秀本科毕业论文(设计)指导教师(本科生 张璇、董林、彭程、田欣熠、马瀚宇);2020年公司“优秀研究生导师”
学会会员 (Membership)
中国细胞生物学学会;中国遗传学会;美国细胞生物学学会(ASCB)
社会服务 (Public service)
审稿:Autophagy, Molecular Biology of the Cell, Current Genetics, Cell Biology International; 基金评审:The Health and Medical Research Fund (HMRF) of Hong Kong; Netherlands Organisation for Scientific Research (NWO); 国家自然科学基金;北京市自然科学基金;江苏省自然科学基金
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